20mg/mL分子量593" />
別名
N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate
應(yīng)用
GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:to study the anticancer effects of statins along with GGTI 298to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endotheliumto evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population
生化/生理作用
GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.
Sigma-Aldrich西格瑪奧德里奇(上海)貿(mào)易有限公司
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