Description
DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. A locus forming an DNA:RNA creates a double-stranded A/B intermediate conformation, with a second target for single-stranded nucleic acid binding proteins on the complementary, displaced DNA strand. They are shown to be resistant to the activity of DNA methyltransferases. The formation of DNA:RNA hybrids has been associated with a number of neurological diseases. Mutations in the DNA:RNA helicase senataxin (SETX) are implicated in the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia oculomotor apraxia type 2.
Catalog No.
RGK60001
Host species
mouse
Tested applications
CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IP, SPR, IF
Species reactivity
General
Form
liquid
Storage buffer
0.01M PBS, pH 7.4.
Concentration
0.58 mg/ml
Purity
>95%
Clonality
Monoclonal
Isotype
IgG2a, kappa
Applications
CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IP, SPR, IF
Purification
Protein A or G purified from cell culture supernatant.
Endotoxin level
Please contact with the lab for this information.
Expression system
Mammalian cells
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
Alternative Names
DNA-RNA Hybrid
Note
For research use only.
關(guān)鍵字: DNA-RNA Hybrid ;S9.6;
武漢佰樂博生物(Biolab Reagents)由五位畢業(yè)于華中科技大學(xué),華中農(nóng)業(yè)大學(xué),武漢大學(xué)等知名高校,且具有二十年工作經(jīng)驗(yàn)的生命科學(xué)領(lǐng)域頂級研究者創(chuàng)立于2021年,憑借豐富的產(chǎn)品開發(fā)經(jīng)驗(yàn),利用全球領(lǐng)先的技術(shù)平臺,引進(jìn)和整合全球高品質(zhì)的蛋白、抗體和試劑盒產(chǎn)品。目前,佰樂博生物作為法國AntibodySystem和ProteoGenix在亞洲的獨(dú)家總代理,提供近30,000種生命科學(xué)試劑,核心產(chǎn)品涵蓋蛋白、抗體和試劑盒,旨在為科研工作者提供專業(yè)、全面、可靠的試劑支持,推動生命科學(xué)研究的深入發(fā)展。