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抗-DNA-RNA雜交抗體,Anti-DNA-RNA Hybrid Antibody(S9.6) (RGK60001)
  • 抗-DNA-RNA雜交抗體,Anti-DNA-RNA Hybrid Antibody(S9.6) (RGK60001)

Anti-DNA:RNA hybrid抗體[clone:S9.6]

價(jià)格 2300
包裝 1支
最小起訂量 1支
發(fā)貨地 湖北
更新日期 2024-12-26
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產(chǎn)品詳情

中文名稱:抗-DNA-RNA雜交抗體英文名稱:Anti-DNA-RNA Hybrid Antibody(S9.6) (RGK60001)
品牌: AS產(chǎn)地: 法國(guó)
保存條件: -20°C純度規(guī)格: PAGE:>95%
產(chǎn)品類別: 一抗 InVivo活性抗體
抗體名: Anti-DNA-RNA Hybrid Antibody(S9.6) (RGK60001)靶點(diǎn): DNA-RNA,antibody,抗體
宿主: mouse適應(yīng)物種: General
克隆性: Monoclonal貨號(hào): RGK60001
貨號(hào):: RGK60001應(yīng)用:: CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IP, SPR, IF
描述: DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. A locus forming an DNA:RNA creates a double-stranded A/B intermediate conformation, with a second target for single-stranded nucleic acid binding proteins on the complementary, displaced DNA strand. They are shown to be resistant to the activity of DNA methyltransferases. The formation of DNA:RNA hybrids has been associated with a number of neurological diseases. Mutations in the DNA:RNA helicase senataxin (SETX) are implicated in the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia oculomotor apraxia type 2.
2024-12-26 抗-DNA-RNA雜交抗體 Anti-DNA-RNA Hybrid Antibody(S9.6) (RGK60001) 1支/2300RMB 2300 AS 法國(guó) -20°C PAGE:>95% 一抗 InVivo活性抗體

Description

DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. A locus forming an DNA:RNA creates a double-stranded A/B intermediate conformation, with a second target for single-stranded nucleic acid binding proteins on the complementary, displaced DNA strand. They are shown to be resistant to the activity of DNA methyltransferases. The formation of DNA:RNA hybrids has been associated with a number of neurological diseases. Mutations in the DNA:RNA helicase senataxin (SETX) are implicated in the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia oculomotor apraxia type 2.


Catalog No.

RGK60001


Host species

mouse


Tested applications

CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IP, SPR, IF


Species reactivity

General


Form

liquid


Storage buffer

0.01M PBS, pH 7.4.


Concentration

0.74 mg/ml


Purity

>95%


Clonality

Monoclonal


Isotype

IgG2a, kappa


Applications

CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IP, SPR, IF


Purification

Protein A or G purified from cell culture supernatant.


Endotoxin level

Please contact with the lab for this information.


Expression system

Mammalian cells


Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.


Reconstitution

Reconstitute in sterile water for a stock solution.


Alternative Names

DNA-RNA Hybrid


Note

For research use only.

Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids. PMID: 33830170

Immunoprecipitation of DNA:RNA Hybrids Using the S9.6 Antibody. PMID: 32681514

High-resolution, strand-specific R-loop mapping via S9.6-based DNA-RNA immunoprecipitation and high-throughput sequencing. PMID: 31053798

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage. PMID: 29742442

The monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences. PMID: 28594954

Structural basis of R-loop recognition by the S9.6 monoclonal antibody. PMID: 35347133

Best practices for the visualization, mapping, and manipulation of R-loops. PMID: 33411340

Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging. PMID: 34232287

The Affinity of the S9.6 Antibody for Double-Stranded RNAs Impacts the Accurate Mapping of R-Loops in Fission Yeast. PMID: 29289567

The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6. PMID: 23784994

Modifications and interactions at the R-loop. PMID: 32961406

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. PMID: 24896180

R-Loop Analysis by Dot-Blot. PMID: 33554969

Amplification-Free and Mix-and-Read Analysis of Multiplexed MicroRNAs on a Single Plasmonic Microbead. PMID: 34324345

New insight into the biology of R-loops. PMID: 32516653

Detection of Telomeric DNA:RNA Hybrids Using TeloDRIP-qPCR. PMID: 33371452

Ultra-deep Coverage Single-molecule R-loop Footprinting Reveals Principles of R-loop Formation. PMID: 32105733

Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids. PMID: 25890199

Development of electrochemical biosensors for simultaneous multiplex detection of microRNA for breast cancer screening. PMID: 34495394







關(guān)鍵字: DNA-RNA,antibody,抗體;s9.6,經(jīng)典抗體;

公司簡(jiǎn)介

武漢佰樂博生物(Biolab Reagents)由五位畢業(yè)于華中科技大學(xué),華中農(nóng)業(yè)大學(xué),武漢大學(xué)等知名高校,且具有二十年工作經(jīng)驗(yàn)的生命科學(xué)領(lǐng)域頂級(jí)研究者創(chuàng)立于2021年,憑借豐富的產(chǎn)品開發(fā)經(jīng)驗(yàn),利用全球領(lǐng)先的技術(shù)平臺(tái),引進(jìn)和整合全球高品質(zhì)的蛋白、抗體和試劑盒產(chǎn)品。目前,佰樂博生物作為法國(guó)AntibodySystem和ProteoGenix在亞洲的獨(dú)家總代理,提供近30,000種生命科學(xué)試劑,核心產(chǎn)品涵蓋蛋白、抗體和試劑盒,旨在為科研工作者提供專業(yè)、全面、可靠的試劑支持,推動(dòng)生命科學(xué)研究的深入發(fā)展。
成立日期 2021-04-08 (4年) 注冊(cè)資本 一千萬元人民幣
員工人數(shù) 100-500人 年?duì)I業(yè)額 ¥ 1000萬-5000萬
主營(yíng)行業(yè) 生物化工,技術(shù)服務(wù) 經(jīng)營(yíng)模式 試劑
  • 武漢佰樂博生物技術(shù)有限公司
VIP 3年
  • 公司成立:4年
  • 注冊(cè)資本:一千萬元人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:高活性重組蛋白,功能性抗體試劑,試劑盒等
  • 公司地址:東湖新技術(shù)開發(fā)區(qū)神墩四路666號(hào)C棟2層
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Anti-DNA:RNA hybrid抗體[clone:S9.6]相關(guān)廠家報(bào)價(jià)

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