Rabbit Anti-DAB2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:DAB2
IR:Immunogen Range:31-130/770
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1601
Swiss Prot:P98082
Source:KLH conjugated synthetic peptide derived from human DAB2:31-130/770
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1ug/Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Rabbit
Guinea Pig
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： DAB2;Differentially expre;Disabled (Drosophila;DOC2;FLJ26626;Mitogen ;responsive ;DAB2_HUMAN;
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