Product Name：μ-conotoxin PIIIA
CAS No.：N/A
Synonyms：μ-芋螺毒素mu-conotoxin PIIIA
Catalog No.：218P262
Brand：HongTide（上海鴻肽生物）
Description：μ-conotoxin PIIIA是已從紫錐花的毒液中分離出來(lái)多肽，是一條含有22個(gè)氨基酸的環(huán)狀多肽，結(jié)構(gòu)中含有三隊(duì)二硫鍵。μ-conotoxin PIIIA能結(jié)合并阻斷電壓門控鈉通道的位點(diǎn) 1，這種毒素會(huì)阻斷神經(jīng)元鈉通道 Nav1.2 (SCN2A) 和 Nav1.7 (SCN9A)。μ-conotoxin PIIIA導(dǎo)致小鼠和魚(yú)的弛緩性麻痹，可阻斷電壓門控鈉通道 (Nav)。μ-conotoxin PIIIA還可有效阻斷 rNav1.2/SCN2A 和 rNav1.4/SCN4A，還適度阻斷 rNav1.1/SCN1A、rNav1.3/SCN3A、rNav1.5/SCN5A 和 mNav1.6/SCN8A。μ-conotoxin PIIIA的抑制是可逆的。
μ- Conotoxin PIIIA is a peptide that has been isolated from the venom of Echinacea purpurea. It is a cyclic peptide containing 22 amino acids and contains three disulfide bonds in its structure. μ- Conotoxin PIIIA can bind and block site 1 of voltage gated sodium channels, and this toxin can block neuronal sodium channels Nav1.2 (SCN2A) and Nav1.7 (SCN9A). μ- Conotoxin PIIIA causes flaccid paralysis in mice and fish, which can block the voltage gated sodium channel (Nav). μ- Conotoxin PIIIA can also effectively block rNav1.2/SCN2A and rNav1.4/SCN4A, and moderately block rNav1.1/SCN1A, rNav1.3/SCN3A, rNav1.5/SCN5A, and mNav1.6/SCN8A. μ- The inhibition of conotoxin PIIIA is reversible.
Purity (HPLC) ≥95.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Pyr-RLCCGF-Hyp-KSCRSRQCK-Hyp-HRCC-NH2(Disulfide bridge：Cys4-Cys16;Cys5-Cys21;Cys11-Cys22) |
Sequence(3-letter code) | Pyr-Arg-Leu-Cys-Cys-Gly-Phe-Hyp-Lys-Ser-Cys-Arg-Ser-Arg-Gln-Cys-Lys-Hyp-His-Arg-Cys-Cys-NH2(Disulfide bridge：Cys4-Cys16;Cys5-Cys21;Cys11-Cys22) |
Peptide Structure | 
|
Molecular Formula | C103H166N40O28S6 |
Molecular Weight | 2605.07 |
訂購(gòu)聯(lián)系方式：
上海鴻肽生物科技有限公司
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郵箱：sales1@hongtide.com
關(guān)鍵字： μ-芋螺毒素;μ-conotoxin PIIIA;mu-conotoxin PIIIA;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡(jiǎn)稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。