Host:Rabbit
Target Protein:CHMP2B
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:25978
Swiss Prot:Q9UQN3
Source:Recombinant protein within C-terminal Human CHMP2B.:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP2B, also known as CHMP2.5 or vacuolar protein-sorting-associated protein 2-2, is a 213 amino acid cytosolic protein. Widely expressed in brain, heart, skeletal muscle, small intestine, pancreas, lung, placenta and leukocytes, CHMP2B associates directly with CHMP2A and vps4 for the disassembly of the ESCRT-III complex. Defects in the gene encoding CHMP2B have been shown to cause chromosome 3-linked frontotemporal dementia (FTD3).
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-1000)
IHC-P(1:50-200)
ICC(1:50-100)
Cross Reactive Species:Human
Mouse
Rat
本產品僅供科研使用。不能用于人和動物治療等其它臨床診斷使用！
關鍵字： VPS2B;CHMP2.5;Vps2-2;CHMP2B;DMT1;
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