Host:Rabbit

Target Protein:PSMB8

IR:Immunogen Range:

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:5696

Swiss Prot:P28062

Source:Recombinant human PSMB8 protein: 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008].

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
IHC-P(1:200-400)
Flow-Cyt(1:50-100)
ICC(1:50-100)
IF(1:50-100)

Cross Reactive Species:Human
Mouse
Rat

本產(chǎn)品僅供科研使用。不能用于人和動物治療等其它臨床診斷使用！