Host:Rabbit
Target Protein:Rad51
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:5888
Swiss Prot:Q06609
Source:KLH conjugated synthetic peptide derived from human Rad51:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500)
IP(1:10-50)
IHC-P(1:50-200)
IHC-F(1:50-200)
Flow-Cyt(1:50)
ICC(1:50)
IF(1:50-200)
Cross Reactive Species:Human
Mouse
Rat
本產(chǎn)品僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷使用！
關(guān)鍵字： Rad51;BRCC5;BRCC 5;BRCC-5;subunit 5;
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