產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號(hào) | 型號(hào) |
Calcium D-Panthotenate | 25g 100g | 137-08-6 | EY-Y0163991 |
Cas No.137-08-6
別名
化學(xué)名
分子式 C18H32CaN2O10
分子量 476.53
溶解度 Soluble in DMSO
儲(chǔ)存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Target: N/A
IC50: N/A
Calcium D-Panthotenate, also named vitamin B5 Calcium, is a water-soluble vitamin for many animals [1, 2]. Pantothenic acid participates in a number of intermediary metabolic reactions as a component of coenzyme A (CoA). It has been reported that pantothenic acid exhibits radioprotective and antioxidative effects and pantothenic acid has the potential to protect against cell damage produced by reactive oxygen species [3].
In vitro: Pantothenic acid (1 mM) increased biosynthesis of glutathione by boosting cell energetic in Jurkat cells [3]. In addition, pantothenic acid (1 mM) protected against oxidative damage and apoptosis in Ehrlich ascites tumour cells [4].
In vivo: Pantothenic acid (200 mg/kg, intraperitoneal injections) completely blocked valproic acid-induced neural tube defects and the decreases in c-Myb and Pim-1 protein expression in CD-1 mice [1]. Moreover, Calcium D-pantothenate (3.39-10.54 mg/kg, diets) increased the intestinal enzymes activities and docosahexaenoic acid (DHA) levels [2].
References:
1. Dawson JE, Raymond AM, Winn LM. Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. Toxicol Appl Pharmacol. 2006;211(2):124-32.
2. Qian Y, Li XF, Zhang DD, Cai DS, Tian HY, Liu WB. Effects of dietary pantothenic acid on growth, intestinal function, anti-oxidative status and fatty acids synthesis of juvenile blunt snout bream Megalobrama amblycephala. PLoS One. 2015;10(3):e0119518.
3. Slyshenkov VS, Dymkowska D, Wojtczak L. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Lett. 2004;569(1-3):169-72.
4. Wojtczak L, Slyshenkov VS. Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals--the role of glutathione. Biofactors. 2003;17(1-4):61-73.
關(guān)鍵字： 137-08-6;C18H32CaN2O10;Calcium D-Panthotena;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè)，公司自成立以來，秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念，立足生物科技領(lǐng)域，運(yùn)用生物技術(shù)和科研試劑，發(fā)展現(xiàn)代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品，服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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