中文名稱

血苷|唾液酸乳糖苷神經(jīng)酰胺；神經(jīng)節(jié)苷脂GM3，一鈉鹽

英文名字

Hematoside|Sialosyllactosylceramide; Ganglioside GM3, monosodium salt

供應(yīng)商

開(kāi)曼生物

產(chǎn)品貨號(hào)

15587-1

背景資料

Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cell signaling events. Gangliosides are often implicated in tumorigenesis since they can modulate cell surface events including proliferation, migration, and adhesion. Ganglioside GM3 is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. At 20 μM, it can suppress angiogenesis and reduce endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.{25490,25485} Furthermore, ganglioside GM3 has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.{25481}

產(chǎn)品描述

A monosialoganglioside that demonstrates both antiproliferative and antiangiogenic effects in tumor cells; dissociates the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance

保存建議

建議您在收到開(kāi)曼生物品牌的Ganglioside GM3 (sodium salt) (1 mg)產(chǎn)品后置于-20度保存，產(chǎn)品有效期為730天.

其他

開(kāi)曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開(kāi)曼生物可提供用于檢測(cè)的特色試劑盒，如：類花生酸類物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.