中文名稱

血苷|唾液酸乳糖苷神經酰胺；神經節(jié)苷脂GM3，一鈉鹽

英文名字

Hematoside|Sialosyllactosylceramide; Ganglioside GM3, monosodium salt

供應商

開曼生物

產品貨號

15587-1

背景資料

Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cell signaling events. Gangliosides are often implicated in tumorigenesis since they can modulate cell surface events including proliferation, migration, and adhesion. Ganglioside GM3 is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. At 20 μM, it can suppress angiogenesis and reduce endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.{25490,25485} Furthermore, ganglioside GM3 has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.{25481}

產品描述

A monosialoganglioside that demonstrates both antiproliferative and antiangiogenic effects in tumor cells; dissociates the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance

保存建議

建議您在收到開曼生物品牌的Ganglioside GM3 (sodium salt) (1 mg)產品后置于-20度保存，產品有效期為730天.

其他

開曼生物向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環(huán)核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.