Name: PF-06463922 acetate
CAS#: 1924207-18-0
Chemical Formula: C23H23FN6O4
Exact Mass: 466.1765
Molecular Weight: 466.4734
Elemental Analysis: C, 59.22; H, 4.97; F, 4.07; N, 18.02; O, 13.72
Description: PF-06463922 acetate is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC).
IUPAC/Chemical Name: (10R).7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H.8,4-(metheno)pyrazolo[4,3.h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile acetate
InChi Key: BLNAIBLTPYGILH-RFVHGSKJSA-N
InChi Code: InChI=1S/C21H19FN6O2.C2H4O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12;1-2(3)4/h4-7,9,11H,10H2,1-3H3,(H2,24,25);1H3,(H,3,4)/t11-;/m1./s1
SMILES Code: N#CC1=C(C(CN2C)=NN1C)C3=CN=C(N)C(O[C@H](C)C4=CC(F)=CC=C4C2=O)=C3.CC(O)=O
Appearance: Solid powder
關(guān)鍵字： 1924207-18-0;PF-06463922 acetate;
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