Name: Avadomide HClCAS#: 1398053-45-6 (HCl)Chemical Formula: C14H15ClN4O3Exact Mass:Molecular Weight: 322.749Elemental Analysis: C, 52.10; H, 4.68; Cl, 10.98; N, 17.36; O, 14.87
Description: Avadomide, also known as CC-122, is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes degradation of Aiolos and Ikaros in diffuse large B-cell lymphoma (DLBCL) and T cells in vitro, in vivo, and in patients, resulting in both cell autonomous as well as immunostimulatory effects.
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