Description: YUM70 is a potent inhibitor of GRP78 (Glucose-regulated protein, 78 kDa). YUM70, inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues. YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis. A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER. Moreover, a YUM70-PROTAC (PROteolysis TArgeting Chimera) was synthesized to force degradation of GRP78 in pancreatic cancer cells. YUM70 showed a strong synergistic cytotoxicity with topotecan and vorinostat.
Chemical Formula: C21H19ClN2O4
Exact Mass: 398.1033
Molecular Weight: 398.843
Elemental Analysis: C, 63.24; H, 4.80; Cl, 8.89; N, 7.02; O, 16.05
Synonym: YUM70; YUM-70; YUM 70;
IUPAC/Chemical Name: N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide
InChi Key: BIQMEYCMAGHOEQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19ClN2O4/c1-2-4-18(25)24-19(12-6-7-16-17(9-12)28-11-27-16)14-10-15(22)13-5-3-8-23-20(13)21(14)26/h3,5-10,19,26H,2,4,11H2,1H3,(H,24,25)
SMILES Code: CCCC(NC(C1=CC=C(OCO2)C2=C1)C3=CC(Cl)=C4C=CC=NC4=C3O)=O
關(guān)鍵字： YUM70;423145-35-1;YUM-70;YUM 70;
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