中文名稱

5-[[4-[（3，4-二氫-6-羥基-2，5，7，8-四甲基-2H-1-苯并吡喃-2-基）甲氧基]苯基]甲基] -2，4-噻唑烷二酮； ResulinTM；曲格列酮

英文名字

5-[[4-[（3，4-dihydro-6-hydroxy-2，5，7，8-tetramethyl-2H-1-benzopyran-2-yl）methoxy]phenyl]methyl]-2，4-thiazlidinedione； ResulinTM； Troglitazone

供應(yīng)商

開曼生物

產(chǎn)品貨號

71750-10

產(chǎn)品報(bào)價(jià)

￥1447.6/10mg

產(chǎn)品說明書

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購買方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

產(chǎn)品新聞

背景資料

Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes， under the trade name ResulinTM， but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPAR.gamma. agonist. The EC50 values for transactivation of human and mouse PPAR.gamma. in a cell-based assay are 0.55 and 0.78 uM， respectively. In the same assay system， no activation of PPAR.alpha. and PPAR.delta. was observed at concentrations up to 10 uM. Troglitazone binds to the PPAR.gamma. ligand-binding domain （LBD） but fails to induce interaction of the PPAR.gamma. LBD with the transcriptional coactivators SRC-1， TIF2， AIB1， p300， or TRAP220. Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 uM.

產(chǎn)品描述

Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes， under the trade name ResulinTM， but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPAR.gamma. agonist. The EC50 values for transactivation of human and mouse PPAR.gamma. in a cell-based assay are 0.55 and 0.78 uM， respectively.{10670} In the same assay system， no activation of PPAR.alpha. and PPAR.delta. was observed at concentrations up to 10 uM. Troglitazone binds to the PPAR.gamma. ligand-binding domain （LBD） but fails to induce interaction of the PPAR.gamma. LBD with the transcriptional coactivators SRC-1， TIF2， AIB1， p300， or TRAP220.{8555} Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 uM.{10669}

保存建議

建議您在收到開曼生物品牌的Troglitazone （10 mg）產(chǎn)品后置于-20度保存，產(chǎn)品有效期為365天.

其他

開曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.作為開曼生物在中國的區(qū)域總代理，艾美捷科技有限公司將為中國客戶提供最全面的開曼生物產(chǎn)品以及客戶訂制化服務(wù).