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英文名稱：
Sorafenib tosylate
CAS號：
284461-73-0
分子式：
C21H16ClF3N4O3
分子量：
464.82
EINECS號：
608-209-4
熔點
202-204°C
沸點
523.3±50.0 °C(Predicted)
密度
1.454±0.06 g/cm3(Predicted)
儲存條件
-20°C Freezer
形態(tài)
White to off-white solid.
酸度系數(shù)(pKa)
12.89±0.70(Predicted)
Sorafenib is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer.
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