英文名稱：
BENZENEACETIC ACID, 4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL)-1-PIPERIDINYL)ETHYL-ALPHA, ALPHA-DIMETHYL-
CAS號(hào)：
202189-78-4
分子式：
C28H37N3O3
分子量：
463.61
EINECS號(hào)：
熔點(diǎn)
202 °C
沸點(diǎn)
639.1±55.0 °C(Predicted)
密度
1.16±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)
4.40±0.10(Predicted)
Bilastine binds to histamine H1-receptors as indicated by its displacement of [3H]-pyrilamine from H1-receptors expressed in guinea-pig cerebellum and human embryonic kidney (HEK) cell lines. The studies conducted on guinea-pig smooth muscle demonstrated the capability of bilastine to antagonise H1-receptors. Bilastine is selective for histamine H1-receptors as shown in receptor-binding screening conducted to determine the binding capacity of bilastine to 30 different receptors . Bilastine distribution has an apparent volume of distribution of 1.29 L/kg, and has an elimination half-life of 14.5 h and plasma protein binding of 84-90% .
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