ZZL-7 NEW
| Price | $47 | $72 | $163 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: ZZL-7 | CAS No.: 99141-91-0 |
| Purity: 99.79% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱(chēng) | ZZL-7 |
| 描述 | ZZL-7 is a fast-onset antidepressant agent that disrupts the interaction between neuronal nitric oxide synthase (nNOS) and the serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). It easily crosses the blood-brain barrier and has research value in major depressive disorder (MDD). |
| 體外活性 | In 293T cells transfected with nNOS and SERT, ZZL-7 (1.0 μM; 2 h) significantly decreases the SERT-nNOS complex level[1]. |
| 體內(nèi)活性 | ZZL-7 (10 mg/kg; intraperitoneal administration) reverses chronic unpredictable mild stress (CMS)-induced depressions behaviors 2 hours after treatment. ZZL-7 (10, 20, and 40 mg/kg; Intragastric administration; once) produces antidepressant-like behaviors dose dependently 2 hours after treatment. ZZL-7 (10 mg/kg, intraperitoneally) causes significantly increases firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. In wild-type mice, ZZL-7 reduces immobility time[1]. |
| 存儲(chǔ)條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 12 mg/mL (49.12 mM) |
| 關(guān)鍵字 | ZZL 7 | ZZL7 | ZZL-7 |
| 相關(guān)產(chǎn)品 | Fluoxetine | DL-Tryptophan | Dapoxetine hydrochloride | Fluvoxamine maleate | Desvenlafaxine succinate hydrate | Desipramine hydrochloride | Milnacipran ((1S-cis) hydrochloride) | Amitriptyline hydrochloride | Dextromilnacipran | Vortioxetine hydrobromide | Fluoxetine hydrochloride | Cinchonidine |
| 相關(guān)庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 神經(jīng)信號(hào)分子庫(kù) | PPI抑制劑庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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