| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI)
CAS:99141-91-0
Purity:大于98% Package:1g,5g,10g,25g根據(jù)客戶需要分裝 Remarks:Not For Human Use, Lab Use Only.
|
| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
021-QQ：65489617 15618227136 |
| Email: |
Sales@ATKchemical.com |
| Products Intro: |
Product Name:L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI)
CAS:99141-91-0
Purity:98% Package:50MG;100MG,1G,5G,100G
|
| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
|
| Tel: |
0571-87213919 |
| Email: |
Eric@peptidego.com |
| Products Intro: |
Product Name:Ac-Ala-Val-OMe
CAS:99141-91-0
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
|
L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) manufacturers
- ZZL-7
-
- $30.00 / 5mg
-
2025-05-10
- CAS:99141-91-0
- Min. Order:
- Purity: 99.79%
- Supply Ability: 10g
- ZZL-7 / Ac-Ala-Val-OMe
-
- $0.00 / 1g
-
2024-09-25
- CAS:99141-91-0
- Min. Order: 1g
- Purity: 99% min
- Supply Ability: 20 tons
|
| | L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Basic information |
| | L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Chemical Properties |
| Melting point | 105 °C | | Boiling point | 442.1±25.0 °C(Predicted) | | density | 1.078±0.06 g/cm3(Predicted) | | storage temp. | -10 to -25°C | | solubility | Soluble to 100 mM in ethanol and to 100 mM in DMSO | | pka | 13.30±0.46(Predicted) | | form | Oil | | color | White to off-white |
| | L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Usage And Synthesis |
| Uses | ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD)[1]. | | Biological Activity | ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), which reduces extracellular 5-HT concentration and down-regulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 can readily cross the blood-brain barrier. | | in vivo | ZZL-7 (10 mg/kg, intraperitoneally) causes significantly increases firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. In wild-type mice, ZZL-7 reduces immobility time[1].
Intragastric administration of ZZL-7 (10, 20, and 40 mg/kg; once) produces antidepressant-like behaviors dose dependently 2 hours after treatment[1].
ZZL-7 (10 mg/kg; intraperitoneal administration) reverses chronic unpredictable mild stress (CMS)-induced depressions behaviors 2 hours after treatment[1]. | Animal Model: | SERT-Cre mice[1] | | Dosage: | 10 mg/kg | | Administration: | i.p.; once | | Result: | Significantly increased firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. |
| | storage | Store at -20°C | | References | [1] Nan Sun, et al. Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science. 2022 Oct 28;378(6618):390-398. DOI:10.1126/science.abo3566 |
| | L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Preparation Products And Raw materials |
|