XL413 HCl NEW
| Price | $57 | $122 | $169 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: XL413 HCl | CAS No.: 1169562-71-3 |
| Purity: 99.67% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | XL413 HCl |
| 描述 | XL413 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.XL413 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.XL413 HCl showed an EC50 value of 118 against pMCM. |
| 體外活性 | XL413 HCl shows cytotoxic effects on tumors, with IC50 of 22.9 μM in HCC1954 cells and 1.1 μM in Colo-205 cells.[2] BMS-863233 HCl is an effective DDK inhibitor in vitro, with an IC50 of 22.7 nM.[2] XL413 HCl is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells.[2] |
| 體內(nèi)活性 | XL413 HCl (10, 30, or 100 mg/kg; p.o.; mice) is well tolerated at all doses, with no significant body weight loss.[1] XL413 HCl (100 mg/kg; p.o.; mice) show excellent plasma exposures in mice and possesses good PK properties.[1] |
| 存儲條件 | store at low temperature | Shipping with blue ice. |
| 溶解度 | H2O : 9.0 mg/mL, Sonication is recommended. DMSO : 3.1 mg/mL, Sonication and heating are recommended. |
| 關(guān)鍵字 | XL413 Hydrochloride | XL 413 Hydrochloride | XL-413 Hydrochloride |
| 相關(guān)產(chǎn)品 | Ribociclib | CASIN | Palbociclib | Abemaciclib | Dinaciclib | Abemaciclib methanesulfonate |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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