Vinorelbine NEW
| Price | $90 |
| Package | 20mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Vinorelbine | CAS No.: 71486-22-1 |
| Purity: 99.64% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱(chēng) | Vinorelbine |
| 描述 | Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. |
| 激酶實(shí)驗(yàn) | Reverse transcriptase assays: Reverse transcriptase assays are carried out in a reaction mixture (50 μL) containing 50 mM Tris-HCl (pH 7.5), 5 mM DTT, 100 mM potassium chloride, 0.01% Triton X-100 or NP40, 10 μg/ml (dT)15.(A)n as template primer and [3H] deoxythymidine triphospahate. The reaction mixture is incubated for 1 hr at 37 ℃ and stopped by the addition of 50 μg of yeast tRNA and 2 mL of 10% solution of trichloroacetic acid containing 1 mM sodium pyrophosphate. The samples are filtered on filters (0.45 μm), washed first with 5% TCA solution for 5 times and then with 2 ml of 70% ethanol. The filters are dried, scintillation fluid is added and the radioactivity counted in a counter. |
| 體外活性 | Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at 1.25 nM, with no cells in anaphase at 8 nM[1]. It time-dependently induces p53 and p21WAF1/CIP1 expression in androgen-dependent (AD) and -independent (AI) prostate cancer cell lines and stimulates reporter genes in a concentration-dependent manner[2]. |
| 體內(nèi)活性 | After vinorelbine treatment, the initial neutropenic episode occurred after the first administration in four dogs, the second in one dog, and the sixth in another dog [3]. In tumor-bearing cats, vinorelbine is tolerated at a weekly interval with a maximum tolerated dose (MTD) of 11.5 mg/m2 [4]. |
| 存儲(chǔ)條件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 10 mg/mL (12.84 mM) DMSO : 100 mg/mL (128.38 mM) |
| 關(guān)鍵字 | Vinorelbine |
| 相關(guān)產(chǎn)品 | Flubendazole | Mebendazole | N-Phenylbenzylamine | 4-Isopropoxybenzoic acid | Oxfendazole | Docetaxel | Thiabendazole | Methylene Blue | Methylene Blue trihydrate | Griseofulvin | Paclitaxel | 4'-Demethylepipodophyllotoxin |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 中藥單體化合物庫(kù) | 生物堿類(lèi)天然產(chǎn)物庫(kù) | 植物來(lái)源化合物庫(kù) | 抗癌臨床化合物庫(kù) | 天然產(chǎn)物庫(kù) | 抗癌上市藥物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗癌藥物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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