Vinorelbine NEW
| Price | $90 |
| Package | 20mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Vinorelbine | CAS No.: 71486-22-1 |
| Purity: 99.64% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱(chēng) | Vinorelbine |
| 描述 | Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. |
| 激酶實(shí)驗(yàn) | Reverse transcriptase assays: Reverse transcriptase assays are carried out in a reaction mixture (50 μL) containing 50 mM Tris-HCl (pH 7.5), 5 mM DTT, 100 mM potassium chloride, 0.01% Triton X-100 or NP40, 10 μg/ml (dT)15.(A)n as template primer and [3H] deoxythymidine triphospahate. The reaction mixture is incubated for 1 hr at 37 ℃ and stopped by the addition of 50 μg of yeast tRNA and 2 mL of 10% solution of trichloroacetic acid containing 1 mM sodium pyrophosphate. The samples are filtered on filters (0.45 μm), washed first with 5% TCA solution for 5 times and then with 2 ml of 70% ethanol. The filters are dried, scintillation fluid is added and the radioactivity counted in a counter. |
| 體外活性 | Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at 1.25 nM, with no cells in anaphase at 8 nM[1]. It time-dependently induces p53 and p21WAF1/CIP1 expression in androgen-dependent (AD) and -independent (AI) prostate cancer cell lines and stimulates reporter genes in a concentration-dependent manner[2]. |
| 體內(nèi)活性 | After vinorelbine treatment, the initial neutropenic episode occurred after the first administration in four dogs, the second in one dog, and the sixth in another dog [3]. In tumor-bearing cats, vinorelbine is tolerated at a weekly interval with a maximum tolerated dose (MTD) of 11.5 mg/m2 [4]. |
| 存儲(chǔ)條件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 10 mg/mL (12.84 mM) DMSO : 100 mg/mL (128.38 mM) |
| 關(guān)鍵字 | Vinorelbine |
| 相關(guān)產(chǎn)品 | Flubendazole | Mebendazole | N-Phenylbenzylamine | 4-Isopropoxybenzoic acid | Oxfendazole | Docetaxel | Thiabendazole | Methylene Blue | Methylene Blue trihydrate | Griseofulvin | Paclitaxel | 4'-Demethylepipodophyllotoxin |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 中藥單體化合物庫(kù) | 生物堿類(lèi)天然產(chǎn)物庫(kù) | 植物來(lái)源化合物庫(kù) | 抗癌臨床化合物庫(kù) | 天然產(chǎn)物庫(kù) | 抗癌上市藥物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗癌藥物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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