Uridine NEW
| Price | $54 | $87 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Uridine | CAS No.: 58-96-8 |
| Purity: 99.63% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Uridine |
| Description | Uridine (Uridin) is a nucleoside compound, one of the four bases that make up RNA, that replaces thymine in DNA during transcription and pairs with adenine. |
| Kinase Assay | Microtubule depolymerizing activity: The effects of 2-Methoxyestradiol on cellular microtubule depolymerization are determined by indirect immunofluorescence techniques in rat aortic smooth muscle A-10 cells. Microtubules are visualized using a β-tubulin antibody. Three viewers determines the percent microtubule loss for each treatment concentration. The data are averaged and plotted as percent microtubule loss versus drug concentration and the EC50s for microtubule depolymerization calculated from the log dose–response curves. |
| In vitro | METHODS: HCC cells HEPG2, HLF and 97H were treated with Uridine (0-600 μM) for 48 h. Cell viability was measured by CCK8 assay. RESULTS: The proliferative capacity of the three HCC cells was significantly inhibited in a dose-dependent manner. [1] METHODS: Differentiated PC-12 cells were treated with Uridine (50 μM) for 4 days, and the expression levels of target proteins were measured by Western Blot. RESULTS: Uridine treatment enhanced neurofilament expression in differentiated PC12 cells, and NF-M and NF-70 expression were significantly increased after Uridine treatment. [2] |
| In vivo | METHODS: To detect anti-tumor activity in vivo, Uridine (100-300 mg/kg) was injected locally into BALB/c nude mice bearing 97H xenografts once daily for sixteen days. RESULTS: Both doses of Uridine significantly reduced the tumor size of subcutaneous tumors in HCC nude mice in a dose-dependent manner. [1] |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 46 mg/mL (188.4 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : 45 mg/mL (184.3 mM) |
| Keywords | beta-Uridine | inhibit | Endogenous Metabolite | Uridine | Inhibitor | NSC-20256 | Nucleoside Antimetabolite/Analog | NSC20256 | b-Uridine |
| Related Compound Libraries | Drug Repurposing Compound Library | Natural Product Library | Anti-Viral Compound Library | Tobacco Monomer Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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