SCH-1473759 hydrochloride NEW
| Price | $113 | $217 | $380 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: SCH-1473759 hydrochloride | CAS No.: 1094067-13-6 |
| Supply Ability: 10g | Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | SCH-1473759 hydrochloride |
| 描述 | SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively). |
| 體外活性 | SCH-1473759 directly binds to aurora A and B (Kds of 20 and 30 nM, respectively) and inhibits the Src family of kinases (IC50 less than 10 nM), Chk1 (IC50 of 13 nM), VEGFR2 (IC50 of 1 nM), and IRAK4 (IC50 of 37 nM). It inhibits tumor cell lines from various tissues, including breast, ovarian, prostate, lung, colon, brain, gastric, renal, skin, and leukemia. The most sensitive cell lines include A2780, LNCap, N87, Molt4, K562, and CCRF-CEM with IC50 values <5 nM [2]. |
| 體內(nèi)活性 | SCH-1473759(5 mg/kg ,ip, bid) was well tolerated in the continuous dosing regimen and showed 50% tumor growth inhibition (TGI) on day 16. SCH-1473759(10mg/kg,ip, bid) is well-tolerated in an intermittent schedule (5 days on, 5 days off) and gave 69% TGI on day 16. SCH-1473759 showed good exposure in all species, with high clearance rates in rodents and moderate clearance rates in dogs and monkeys.The half-life is also moderate, but the tissue distribution is high[1]. SCH 1473759 dose- and schedule-dependent anti-tumor activity in four human tumor xenograft models. Further, the efficacy is enhanced in combination with taxanes and found to be most efficacious when SCH 1473759 is dosed 12-h post-taxane treatment[2]. |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 70 mg/mL (151.19 mM), Sonication is recommended. |
| 關鍵字 | SCH1473759 Hydrochloride | Aurora Kinase | inhibit | SCH1473759 | Inhibitor | SCH 1473759 | SCH 1473759 Hydrochloride | SCH1473759 hydrochloride | SCH 1473759 hydrochloride | SCH-1473759 Hydrochloride | SCH-1473759 |
| 相關產(chǎn)品 | Palmatine chloride | MK-8745 | SC-514 | Barasertib-HQPA | MBM-55S | SP600125 | KW-2449 | Palmatine | Alisertib | TAK-901 | Tozasertib | TCS7010 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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