SCH-23390 hydrochloride NEW
| Price | $33 | $46 | $71 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: SCH-23390 hydrochloride | CAS No.: 125941-87-9 |
| Purity: 99.51% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | SCH-23390 hydrochloride |
| 描述 | SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors. |
| 動物實驗 | Rats are injected with SCH 23390(0, 1, or 10 μg/kg i.p.). |
| 體外活性 | SCH23390 blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells (IC50=268 nM).SCH 23390 also shows high affinity (Ki=9.3 nM) at h5-HT2C sites. |
| 體內(nèi)活性 | In the rat, the repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%). |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 25 mg/mL (77.10 mM), Sonication is recommended. DMSO : 50 mg/mL (154.21 mM) |
| 關(guān)鍵字 | 5-hydroxytryptamine Receptor | SCH 23390 hydrochloride | SCH23390 | SCH 23390 | Inhibitor | epileptiform | constriction | inhibit | R-SCH23390 Hydrochloride | DA1-like | ductus | 5‐HT1C | GIRK | R-SCH-23390 Hydrochloride | 5-HT Receptor | SCH-23390 Hydrochloride | SCH23390 Hydrochloride | R-SCH 23390 Hydrochloride | enantioselective | D5-receptor | Dopamine Receptor | SCH 23390 Hydrochloride | 5‐HT2 | KcsA | SCH-23390 | Serotonin Receptor | SCH23390 hydrochloride | neurological | Potassium Channel |
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Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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