pyridoxal isonicotinoyl hydrazone NEW
| Price | $39 | $53 |
| Package | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: pyridoxal isonicotinoyl hydrazone | CAS No.: 737-86-0 |
| Purity: 99.74% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | pyridoxal isonicotinoyl hydrazone |
| Description | pyridoxal isonicotinoyl hydrazone (PIH) is a cell-permeable and relatively non-toxic iron (Fe3+) chelator that shows high iron chelation efficacy both in vitro and in vivo. |
| In vitro | After a 60-minute reincubation of 59Fe-labeled reticulocytes with tris-hydroxamate deferoxamine (5 mmol/L), 3.5% of cellular 59Fe was released, although Pyridoxal isonicotinoyl hydrazone (PIH) at a 50-fold lower concentration (0.1 mmol/L) released 38.6% of cellular 59Fe [1]. In primary human hepatocytes and the human hepatocellular carcinoma cell line HepG2/C3A, PIH treatment decreases Fech protein levels, but not Fech mRNA levels; and PIH is detected after isoniazid treatment, with levels increasing further when exogenous vitamin B6 analogs are coadministered [2]. |
| In vivo | Intraperitoneal administration of PIH to mice (5 mg/25 gm mouse/day) over 6 days decreased 59Fe levels in the liver, spleen, and kidney but not in the blood. After oral administration, PIH resulted in an eightfold increase in fecal Fe excretion and possibly some urinary excretion of Fe [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 28.63 mg/mL (100 mM) |
| Keywords | inhibit | pyridoxal isonicotinoyl hydrazone | Inhibitor |
| Related Compound Libraries | Ferroptosis Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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