Protirelin NEW
| Price | $47 | $65 | $135 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Protirelin | CAS No.: 24305-27-9 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Protirelin |
| Description | Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin. |
| Animal Research | Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted. |
| In vivo | Protirelin (TRH), a neuropeptide predating the split between protostomes and deuterostomes, has likely played a role in regulating postembryonic growth and reproduction from its evolutionary origins. This study explores Protirelin's impact on body temperature, specifically through the administration of 1, 5, 10, and 20 mg/kg doses intraperitoneally to male Wistar rats (200-250 g). The findings reveal that Protirelin induces a temporary, dose-dependent increase in body temperature. Notably, thyroidectomized rats receiving a 20 mg/kg dose of Protirelin do not exhibit the significant hyperthermia observed in sham-operated counterparts, indicating that thyroid hormone release may be essential to Protirelin's hyperthermic effect. |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 67 mg/mL (184.9 mM) DMSO : 67 mg/mL (184.9 mM) H2O : 66 mg/mL (182.1 mM) |
| Keywords | Thyroid Hormone Receptor | THR | Protirelin | Inhibitor | inhibit | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Oleamide | Glycerol | Thymidine | Naringin | Oleic acid | 3-Indoleacetic acid | Oxalic acid dihydrate |
| Related Compound Libraries | Nuclear Receptor Compound Library | FDA-Approved & Pharmacopeia Drug Library | Approved Drug Library | ReFRAME Related Library | Drug Repurposing Compound Library | Endocrinology-Hormone Compound Library | Natural Product Library for HTS | FDA-Approved Drug Library | RO5 Drug-like Natural Product Library | Human Endogenous Metabolite Compound Library Plus |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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