Product Details
| Product Name:
PQCA |
CAS No.:
1144504-35-7 |
| Purity:
98.95% |
Supply Ability:
10g |
| Release date:
2025/04/27 |
Product Introduction
Bioactivity
| Name | PQCA |
| Description | PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease. |
| In vivo | In male rhesus monkeys, oral administration of PQCA (3-30 mg/kg) effectively mitigates the cognitive impairments induced by scopolamine in both the paired-associates learning (PAL) and the continuous performance task (CPT). Scopolamine-induced blockade of muscarinic signaling results in significant deficits in performance on both tasks. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : ＜1 mg/mL (insoluble or slightly soluble), Sonication and heating to 80℃ are recommended.
|
| Keywords | PQCA | mAChR |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | (+)-Sparteine | Clozapine N-Oxide | Pilocarpine nitrate | Ribavirin | D-Menthol | Amitriptyline hydrochloride | Choline chloride | Propoxur |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$47.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-04-27 |
United States