Paromomycin Sulfate NEW
| Price | $41 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Paromomycin Sulfate | CAS No.: 1263-89-4 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Paromomycin Sulfate |
| 描述 | Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Paromomycin Sulfate (Aminosidine sulfate) is the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. |
| 激酶實(shí)驗(yàn) | Concentration–response and kinetic studies: The microsomal protein (30 μg), [1β-3H]androstenedione (6.6 × 105 dpm) and NADPH (270 μM) are used for the concentration–response experiment with an incubation time of 20 minutes. The Aminoglutethimide is initially tested at 10 μM and 100 μM concentrations, followed by a full concentration–response study with at least 8 concentrations ranging from 0.01 μM to 160 μM. For the initial velocity study the concentration of [1β-3H]androstenedione is varied from 7.5 to 100 nM and the incubation time is set to 5 minutes. The tritiated water formed during the conversion of the tritiated substrate, [1β-3H]androstenedione, to estrone is quantified by liquid scintillation counting. Each assay is performed three times in duplicate and the results are treated by nonlinear regression analysis allowing the determination of the half-maximal inhibitory concentration (IC50). |
| 體外活性 | In both clinical cases and experimental models of cutaneous leishmaniasis (CL), lesions caused by L. major show a faster and more complete recovery when treated with paromomycin ointment as compared to those caused by L. panamensis and L. amazonensis. |
| 體內(nèi)活性 | Paromomycin, an aminoglycoside antibiotic, exhibits robust antimicrobial activity against a broad spectrum of Gram-positive bacteria, Gram-negative bacteria, some protozoa, and tapeworms. In vitro analysis of amastigote sensitivity within a mouse macrophage model indicated that L. tropica and the L. major strains (ED50s: 1~5 μM) are more sensitive to Paromomycin than L. mexicana (ED50: 39 μM) and L. braziliensis (ED50: <12 μM). The L. donovani strain demonstrates moderate sensitivity (ED50: 6~18 μM), with the exception of the Indian strain, DD8, exhibiting significantly reduced susceptibility (ED50 >150 μM). |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 10 mM DMSO : Insoluble |
| 關(guān)鍵字 | Paromomycin Sulfate | Inhibitor | parasitic | Parasite | Aminosidine | giardiasis | tapeworm infection | amebiasis | Antibiotic | Aminosidine Sulfate | inhibit | Bacterial | leishmaniasis | Paromomycin |
| 相關(guān)庫 | 抗寄生蟲庫 | 經(jīng)典已知活性庫 | 藥物功能重定位化合物庫 | 抗寄生蟲天然產(chǎn)物庫 | 抑制劑庫 | FDA 上市藥物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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