Product Details
| Product Name:
MM3122 |
CAS No.:
2574390-27-3 |
| Purity:
100% |
Supply Ability:
10g |
| Release date:
2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | MM3122 |
| 描述 | MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells. |
| 體外活性 | MM3122 (0-1 μM) exhibits inhibitory activity against HGFA, matriptase, hepsin, and thrombin with IC50 values of 32 nM, 0.31 nM, 0.19 nM, and over 20 nM, respectively. Additionally, MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3, and VSV-SARS CoV-2 chimera calu-3 with EC50 values of 74 nM, 0.87 nM, and 0.43 nM, respectively [1]. |
| 體內(nèi)活性 | MM3122, administered intraperitoneally (i.p.) at doses ranging from 0-100 mg/kg daily for 7 days, showed no adverse effects, including no weight loss or changes in harvested organs (liver, spleen, and kidney), when compared to control subjects. Additionally, a single i.p. dose of MM3122 at 16.7 mg/kg was found to have a plasma half-life of 8.6 hours and a lung half-life of 7.5 hours in NSG mice[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 90 mg/mL (135.2 mM), Sonication is recommended.
|
| 關(guān)鍵字 | MM3122 | GTPL-11533 | GTPL 11533 | MM 3122 |
| 相關(guān)產(chǎn)品 | Nirmatrelvir | EIDD-1931 | Remdesivir | Andrographolide | Silymarin | Umifenovir hydrochloride | Hydroxychloroquine | Ritonavir | Chloroquine phosphate | Chloroquine | Favipiravir | Imatinib |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗病毒庫 | 抑制劑庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States