BAY1238097 NEW
| Price | $99 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: BAY1238097 | CAS No.: 1564268-08-1 |
| Purity: 98.55% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | BAY1238097 |
| 描述 | BAY1238097, a potent and selective bromodomain and extra-terminal motif (BET) inhibitor with anticancer activity, exhibits strong antiproliferative effects in AML (Acute Myeloid Leukemia) and MM (Multiple Myeloma) models. BAY1238097 is useful for studying advanced refractory malignancies. |
| 體外活性 | BAY 1238097 exhibits potent inhibitory activity (IC50 < 100 nM) in a TR-FRET assay utilizing BET BRD4 bromodomain 1 and an acetylated peptide derived from histone H4. In the NanoBRET assay, it inhibits the interaction between BRD4 (IC50=63 nM), BRD3, or BRD2 (IC50=609 nM), and H4 (IC50=2430 nM)[2]. BAY 1238097 demonstrates in vitro anti-tumor activity in lymphoma models. It influences the gene expression of GCB DLBCL cells. At the gene level, top downregulated genes include BTK, CCDC86, CCND2, CD19, CD27, FAIM, FCMR (FAIM3), IL7R, IRAK1, MAPK13, MYB, MYC, PDE4B, TNFRSF13B, TNFRSF17. In addition to histone-coding genes, upregulated genes include CCL5, CDKN2C, CD69, JUN, and MKNK2[1]. |
| 體內(nèi)活性 | BAY 1238097 demonstrates robust efficacy in AML and MM models. It exhibits in vivo anti-tumor activity in lymphoma models[1][2]. BAY 1238097 is well tolerated at doses of 10-15 mg/kg administered daily over 9-14 days in various disease models, with no apparent toxicity[1][2]. |
| 存儲條件 | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (221.45 mM), Sonication is recommended. |
| 關(guān)鍵字 | BAY 1238097 | BAY1238097 | BAY-1238097 |
| 相關(guān)產(chǎn)品 | ABBV-744 | CeMMEC1 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | (+)-JQ-1 | J-147 | Anacardic Acid | Curcumin | dBET6 | Piflufolastat | Naphthol AS-E | Bisdemethoxycurcumin | GSK1379725A |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1740.00/100mg |
VIP3Y
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TargetMol Chemicals Inc.
|
2024-10-23 | |
| $99.00/1mg |
VIP3Y
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TargetMol Chemicals Inc.
|
2024-11-12 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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