Loxoribine NEW

Price	$31	$52	$84
Package	5mg	10mg	25mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-14

Product Details

Product Name: Loxoribine	CAS No.: 121288-39-9
Purity: 99.73%	Supply Ability: 10g
Release date: 2024/11/14

Product Introduction

Bioactivity

名稱	Loxoribine
描述	Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.
體外活性	Loxoribine selectively activates innate immune system cells through the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1], leading to the maturation of human monocyte-derived dendritic cells (DCs) and enhancing their Th-1- and Th-17-polarizing capability[2]. Additionally, loxoribine (250 μM; 48 hours) promotes MoDCs maturation, evident from the increased expression of CD80, CD83, CD40, CD54, and CCR7[2].
體內(nèi)活性	In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells[3].
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 27.5 mg/mL (81.05 mM)
關(guān)鍵字	Loxoribine \| natural \| Toll-like Receptor (TLR) \| killer,cells \| Influenza Virus \| Inhibitor \| RWJ-21757 \| RWJ21757 \| cells \| inhibit \| TLR-7 \| MoDCs
相關(guān)產(chǎn)品	Hydroxychloroquine \| Curcumin
相關(guān)庫	經(jīng)典已知活性庫 \| 膜蛋白靶向化合物庫 \| 細(xì)胞焦亡化合物庫 \| 抗病毒庫 \| 已知活性化合物庫 \| 抗感染化合物庫 \| 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.