Valganciclovir hydrochloride NEW
| Price | $30 | $54 | $89 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Valganciclovir hydrochloride | CAS No.: 175865-59-5 |
| Purity: 99.79% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Valganciclovir hydrochloride |
| 描述 | Valganciclovir hydrochloride (Valganciclovir HCl) is a hydrochloride salt form of valganciclovir, a prodrug form of ganciclovir, a nucleoside analog of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, and viral replication. |
| 體外活性 | Valganciclovir is efficiently absorbed through the gastrointestinal tract, with its bioavailability approximately 60% when taken orally after meals. Upon administration, both intestinal and hepatic esterases concurrently hydrolyze the two enantiomers of ganciclovir, inhibiting the replication of human cytomegalovirus. |
| 體內(nèi)活性 | In cells infected with Cytomegalovirus (CMV), Valganciclovir is initially phosphorylated by viral protein kinase to its monophosphate form, then further phosphorylated by cellular kinases to produce its triphosphate form. This triphosphate is slowly metabolized within the cell. The phosphorylation process is dependent on viral kinase and preferentially occurs in virus-infected cells. Ganciclovir's antiviral activity is due to the triphosphate form of ganciclovir, which inhibits viral DNA synthesis. The ganciclovir triphosphate gets incorporated into the DNA, replacing many adenine bases, and hindering DNA synthesis as diester bonds take longer to form, thus diminishing the chain's stability. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 127.94 mM DMSO : 45 mg/mL (115.14 mM) |
| 關(guān)鍵字 | Inhibitor | Cytomegalovirus | Valganciclovir hydrochloride | CMV | Valganciclovir | inhibit | Valganciclovir Hydrochloride |
| 相關(guān)產(chǎn)品 | BTA-188 | (+)-Usnic acid | 2,2'-Anhydrouridine | Tirilazad mesylate | Vidarabine phosphate | Oxytetracycline Hydrochloride | Rociclovir PM | Moroxydine hydrochloride | Arbidol | 3-Methoxycatechol |
| 相關(guān)庫 | FDA上市及藥典收錄分子庫 | 表型篩選靶點(diǎn)鑒定庫 | 經(jīng)典已知活性庫 | 上市藥物庫 | 藥物功能重定位化合物庫 | 抗病毒庫 | 抑制劑庫 | FDA 上市藥物庫 | 口服活性化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1kg |
VIP1Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-04-12 | |
| $0.00/25KG |
VIP2Y
|
shandong perfect biotechnology co.ltd
|
2023-11-15 | |
| $2550.00/1kg |
Hebei Mingeng Biotechnology Co., Ltd
|
2022-04-27 | ||
| $1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-07-15 | |
| $0.00/1Kg/Bag |
VIP4Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-07-09 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-08 | ||
| $0.00/1KG |
VIP4Y
|
Baoji Guokang Bio-Technology Co., Ltd.
|
2021-06-08 | |
| $1.00/1KG |
VIP7Y
|
Career Henan Chemical Co
|
2018-08-07 | |
| $5.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-03 | ||
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-06-26 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY