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Postion:Product Catalog >API>Antineoplastic agents>Hormonal antineoplastic drugs>Letrozole
Letrozole
  • Letrozole
  • Letrozole

Letrozole NEW

Price Get Latest Price
Package 1KG 5KG 25KG
Min. Order: 1KG
Supply Ability: 5,000KG
Update Time: 2024-11-01
Related documents: COA

Product Details

Product Name: Letrozole CAS No.: 112809-51-5
EC-No.: 675-034-8 Min. Order: 1KG
Purity: 99%, USP Supply Ability: 5,000KG
Release date: 2024/11/01
Appearance:: White powder Shelf Life:: 2 years

Description:


Letrozole Overview

Drug Class: Aromatase Inhibitor


Chemical Structure: Letrozole is a non-steroidal compound that inhibits aromatase, an enzyme responsible for converting androgens into estrogens in postmenopausal women.


Mechanism of Action

Letrozole works by blocking the aromatase enzyme, which decreases estrogen levels in the body. Since many breast cancers are estrogen-dependent, lower estrogen levels can slow or stop the growth of these tumors. This mechanism makes letrozole particularly effective in treating hormone receptor-positive breast cancers.


Indications

Early-Stage Breast Cancer: Letrozole is often used after surgery (adjuvant therapy) in postmenopausal women with early-stage, hormone receptor-positive breast cancer to decrease the risk of recurrence.

Advanced or Metastatic Breast Cancer: It is indicated for postmenopausal women with advanced breast cancer that has progressed following anti-estrogen therapy, such as tamoxifen.

Fertility Treatment: Letrozole is sometimes prescribed off-label to induce ovulation in women with infertility issues, particularly those with PCOS. It is considered an alternative to clomiphene citrate due to its favorable side effect profile.

Dosing

Typical Dose: The standard dose for breast cancer treatment is usually 2.5 mg taken once daily. The duration of treatment can vary based on the specific case, often lasting five years or more, depending on the patient’s response and the oncologist's recommendation.

Side Effects

While letrozole is generally well-tolerated, some common side effects include:


Hot Flashes: A common symptom due to decreased estrogen levels.

Joint Pain and Stiffness: Many patients report arthralgia or myalgia.

Fatigue: General tiredness or weakness is frequently experienced.

Bone Density Loss: Long-term use may increase the risk of osteoporosis and fractures due to lower estrogen levels.

Nausea and Vomiting: Some patients may experience gastrointestinal discomfort.

Mood Changes: Depression or anxiety can occur in some individuals.

Contraindications and Precautions

Pregnancy: Letrozole is contraindicated in pregnant women as it may harm a developing fetus.

Lactation: It is not recommended for breastfeeding mothers.

Bone Health: Patients should be monitored for bone density, especially those at risk for osteoporosis.

Monitoring and Follow-Up

Regular follow-up appointments are essential to monitor the effectiveness of the treatment and manage any side effects. Bone density tests may be recommended to assess the impact on bone health, and patients should be encouraged to maintain a healthy lifestyle, including diet and exercise.


Conclusion

Letrozole is a critical medication for managing hormone receptor-positive breast cancer in postmenopausal women. It has a well-established role in both adjuvant and metastatic settings, with emerging applications in fertility treatments. Patients considering or currently using letrozole should work closely with their healthcare providers to optimize their treatment plan and address any concerns related to side effects or overall health.


Product Forms: Injectable Solution, Oral Capsules/Tablets

Payment method: T/T in advance, Paypal, Western Union, L/C, etc.

Shipping ways: Courier, Air, Sea, Road

Storage Condition: Dry, dark, and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).





Company Profile Introduction

We are experts in providing raw materials, resources, customized manufacturing, and much more. We especially pride ourselves on the partnership in the manufacturing of high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients. Among them, our key client industrial sectors around the globe are: Pharmaceuticals. Cosmetics. Nutritional Supplements. And Special Chemicals.

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  • Since: 2013-11-01
  • Address: Room 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Road, Gongshu District, Hangzhou, Z
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