Hesperidin NEW
| Price | $50 | $60 |
| Package | 20mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Hesperidin | CAS No.: 520-26-3 |
| Purity: 97.05% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Hesperidin |
| Description | Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activity. |
| In vitro | METHODS: Tumor cells HeLa and HT-29 were treated with Hesperidin (20-100 μM) for 24-72 h. Cell viability was measured by MTT assay. RESULTS: Treatment with Hesperidin significantly reduced cell viability and the effect of Hesperidin on cell viability was concentration and time dependent. Cells incubated with 100 μM Hesperidin for 72 h showed the greatest antiproliferative effect, with cell viability decreasing to 12% of control cells. [1] METHODS: Human mesothelioma cells MSTO-211H were treated with Hesperidin (40-160 μM) for 48 h. Apoptosis was detected using DAPI and PI staining. RESULTS: The percentage of sub-G1 phase increased from 20% to 35% in 40-160 μM Hesperidi-treated MSTO-211H cells. [2] |
| In vivo | METHODS: To assay antitumor activity in vivo, Hesperidin (200 mg/kg) was administered by gavage to BALB/c mice bearing CT-26 xenografts once daily for five days. Hesperidin was then administered as a single dose of cyclophosphamide (25 mg/kg) for fourteen days. RESULTS: Leukocyte counts were increased in mice treated with Hesperidin prior to cyclophosphamide injection. This significant protective effect was observed 4 and 7 days after cyclophosphamide injection. In CT-26 tumor-bearing mice, co-administration of Hesperidin and cyclophosphamide significantly inhibited cyclophosphamide-induced delay in tumor growth. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (98.27 mM) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 6 mg/mL (9.83 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | citrus | inhibit | Hesperidin | Apoptosis | antiallergic | flavanone | antioxidant | Reactive Oxygen Species | glycoside | inflammatory | antitumor | Autophagy | Endogenous Metabolite | Inhibitor |
| Related Compound Libraries | Flavonoid Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Gut Microbial Metabolite Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
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TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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