Hesperidin NEW
| Price | $50 | $60 |
| Package | 20mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Hesperidin | CAS No.: 520-26-3 |
| Purity: 97.05% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Hesperidin |
| Description | Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activity. |
| In vitro | METHODS: Tumor cells HeLa and HT-29 were treated with Hesperidin (20-100 μM) for 24-72 h. Cell viability was measured by MTT assay. RESULTS: Treatment with Hesperidin significantly reduced cell viability and the effect of Hesperidin on cell viability was concentration and time dependent. Cells incubated with 100 μM Hesperidin for 72 h showed the greatest antiproliferative effect, with cell viability decreasing to 12% of control cells. [1] METHODS: Human mesothelioma cells MSTO-211H were treated with Hesperidin (40-160 μM) for 48 h. Apoptosis was detected using DAPI and PI staining. RESULTS: The percentage of sub-G1 phase increased from 20% to 35% in 40-160 μM Hesperidi-treated MSTO-211H cells. [2] |
| In vivo | METHODS: To assay antitumor activity in vivo, Hesperidin (200 mg/kg) was administered by gavage to BALB/c mice bearing CT-26 xenografts once daily for five days. Hesperidin was then administered as a single dose of cyclophosphamide (25 mg/kg) for fourteen days. RESULTS: Leukocyte counts were increased in mice treated with Hesperidin prior to cyclophosphamide injection. This significant protective effect was observed 4 and 7 days after cyclophosphamide injection. In CT-26 tumor-bearing mice, co-administration of Hesperidin and cyclophosphamide significantly inhibited cyclophosphamide-induced delay in tumor growth. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (98.27 mM) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 6 mg/mL (9.83 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | citrus | inhibit | Hesperidin | Apoptosis | antiallergic | flavanone | antioxidant | Reactive Oxygen Species | glycoside | inflammatory | antitumor | Autophagy | Endogenous Metabolite | Inhibitor |
| Related Compound Libraries | Flavonoid Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Gut Microbial Metabolite Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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