GNE-495 NEW
Price | $66 | $97 | $148 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-15 |
Product Details
Product Name: GNE-495 | CAS No.: 1449277-10-4 |
Purity: 99.22% | Supply Ability: 10g |
Release date: 2024/11/15 |
Product Introduction
Bioactivity
名稱 | GNE-495 |
描述 | GNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM. |
體外活性 | GNE-495 has efficacy in retinal angiogenesis. GNE-495 shows the best balance of MAP4K4 inhibition, permeability, microsomal stability, and cellular potency. |
體內(nèi)活性 | GNE-495 is administered at high doses (25 and 50 mg/kg) intraperitoneally to neonatal mice. This compound demonstrates superior potency and favorable pharmacokinetic (PK) profiles across all tested species, characterized by low clearance rates, moderate terminal half-lives, and acceptable levels of oral bioavailability (F=37-47%). |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 2 mg/mL (4.93 mM), Sonication is recommended. |
關(guān)鍵字 | GNE-495 | MAPK Kinase Kinase Kinase | GNE495 | MAP4K | inhibit | GNE 495 | Inhibitor |
相關(guān)產(chǎn)品 | Sodium lauryl sulfoacetate | Nomilin | Vemurafenib | CMPD1 | SKLB-163 | MBM-55S | sodium lauroyl-α-hydroxyethyl sulfonate | NQDI-1 | Takinib | NG25 | MK2-IN-3 hydrate | Selonsertib |
相關(guān)庫 | 抗結(jié)直腸癌化合物庫 | 成骨分子庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | HIF-1化合物庫 | 激酶抑制劑庫 | 抗卵巢癌化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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