GNE-131 NEW
Price | $123 | $278 | $396 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-14 |
Product Details
Product Name: GNE-131 | CAS No.: 1629063-81-5 |
Purity: 99.59% | Supply Ability: 10g |
Release date: 2024/11/14 |
Product Introduction
Bioactivity
名稱 | GNE-131 |
描述 | GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM). |
體外活性 | GNE-131 shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 (IC50: 0.003 μM). |
體內(nèi)活性 | GNE-131 demonstrates low in vivo clearance in dogs, rats, and mice, and exhibits excellent efficacy in a transgenic mouse model of induced pain [1]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 120 mg/mL (271.14 mM), Sonication is recommended. |
關(guān)鍵字 | GNE131 | Na+ channels | inhibit | Na channels | Inhibitor | GNE 131 | Sodium Channel | GNE-131 |
相關(guān)產(chǎn)品 | Phenytoin sodium | Lidocaine Hydrochloride hydrate | Lidocaine | Valproic Acid | Butamben | Lidocaine hydrochloride | L-Aspartic aicd sodium | Mebeverine hydrochloride | Amitriptyline hydrochloride | Riluzole | Benzocaine | Nefopam hydrochloride |
相關(guān)庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 鈉通道分子庫 | 抑制劑庫 | 神經(jīng)保護化合物庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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