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Postion:Product Catalog >GNE-1858
GNE-1858
  • GNE-1858

GNE-1858 NEW

Price $175 $372 $556
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-14

Product Details

Product Name: GNE-1858 CAS No.: 2680616-96-8
Purity: 98.70% Supply Ability: 10g
Release date: 2024/11/14

Product Introduction

Bioactivity

名稱GNE-1858
描述GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).
體外活性HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function.Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase.
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 4.28 mg/mL (10 mM), Sonication is recommended.
關(guān)鍵字GNE1858 | hematopoietic | MAP4K | proliferation | T-cell | regulator | GNE-1858 | GNE 1858 | Inhibitor | negative-feedback | inhibit | receptor | signaling | MAPK Kinase Kinase Kinase | progenitor
相關(guān)產(chǎn)品Sodium lauryl sulfoacetate | Nomilin | Vemurafenib | CMPD1 | SKLB-163 | MBM-55S | sodium lauroyl-α-hydroxyethyl sulfonate | NQDI-1 | Takinib | NG25 | MK2-IN-3 hydrate | Selonsertib
相關(guān)庫疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抗卵巢癌化合物庫 | 抗肥胖化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 細(xì)胞骨架化合物庫 | 抗癌化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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