gardiquimod TFA salt NEW
Price | $49 |
Package | 2mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: gardiquimod TFA salt | CAS No.: 1159840-61-5 |
Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | gardiquimod TFA salt |
Description | Gardiquimod diTFA, an imidazoquinoline analog and TLR7/8 agonist, inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs), and specifically activates TLR7 at concentrations below 10 μM. As an immune system modifier and reverse transcriptase inhibitor, it serves as a novel therapeutic agent to block systemic and mucosal transmission of HIV-1.[1][2] |
In vitro | Gardiquimod diTFA (6-60 μM ) significantly inhibits HIV-1 reverse transcriptase to synthesis of cDNA [1]. |
In vivo | Gardiquimod, when administered intraperitoneally at a dosage of 1 mg/kg per mouse daily for 7 days, significantly augmented the anti-tumor effects of natural killer (NK) cells in conjunction with dendritic cells (DCs) on human HepG2 liver carcinoma xenografts in male athymic nude mice (Balb-nu/nu, 5 weeks old). This regimen notably suppressed the growth of the carcinoma xenografts, demonstrating the potential of Gardiquimod as a powerful adjunct in cancer immunotherapy strategies. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Keywords | gardiquimod TFA salt | gardiquimod TFA |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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