(E/Z)-Teriflunomide NEW
| Price | $31 | $48 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: (E/Z)-Teriflunomide | CAS No.: 108605-62-5 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | (E/Z)-Teriflunomide |
| 描述 | (E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis. |
| 體外活性 | In animal models of demyelinating diseases, Teriflunomide has demonstrated efficacy. For instance, in the black rat model of autoimmune encephalomyelitis, Teriflunomide has shown both preventive and therapeutic effects; similarly, in female Lewis rat models of Experimental Autoimmune Encephalomyelitis (EAE), it has been effective in ameliorating symptoms and reducing disease exacerbation. |
| 體內(nèi)活性 | Teriflunomide acts as a dihydroorotate dehydrogenase inhibitor, thereby inhibiting the de novo synthesis of pyrimidine in rapidly proliferating cells. By suppressing highly proliferative T and B lymphocytes, Teriflunomide effectively reduces the inflammatory response to self-antigens. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 6.25 mg/mL (23.13 mM), Sonication is recommended. |
| 關(guān)鍵字 | Teriflunomide | HMR1726 | (E/Z)-Teriflunomide | HMR 1726 |
| 相關(guān)產(chǎn)品 | Rotenone | Mycophenolate Mofetil | Isomalt |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 抗病毒庫(kù) | 抑制劑庫(kù) | FDA 上市藥物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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