ELOVL6-IN-1 NEW
| Price | $70 | $175 | $289 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: ELOVL6-IN-1 | CAS No.: 1185736-98-4 |
| Purity: 99.54% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | ELOVL6-IN-1 |
| 描述 | ELOVL6-IN-1 is a potent, orally active, and selective ELOVL6 inhibitor that dose-dependently inhibits mouse ELOVL6 activities with an IC50 value of 0.350 μM. It inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1]. |
| 體外活性 | ELOVL6-IN-1 has sufficiently lipophilic. It has the potential to penetrate the intracellular space in a passive diffusion manner potentially[1]. |
| 體內活性 | ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) shows significant plasma and liver exposure[1]. At doses of 10 and 30 mg/kg (p.o.; 0~2 hours), it reduces the elongation index of liver lipids[1]. Additionally, a dose of 100 mg/kg (p.o.; 2 days) decreases the elongation index of total liver fatty acids[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (90.82 mM), Sonication is recommended. |
| 關鍵字 | selective | potent | palmitoyl-CoA | orally | noncompetitive | malonyl-CoA | Inhibitor | inhibit | ELOVL6-IN-1 | ELOVL-6-IN-1 | ELOVL6IN1 | ELOVL6 IN 1 |
| 相關庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | NO PAINS 化合物庫 | 口服活性化合物庫 | 已知活性化合物庫 | 含氟化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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