EGFR-IN-8 NEW
| Price | $69 | $172 | $286 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: EGFR-IN-8 | CAS No.: 2407957-87-1 |
| Purity: 97.45% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | EGFR-IN-8 |
| 描述 | EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC. |
| 體外活性 | In A549, PC9, H1975, CL68, and CL97?cells, EGFR-IN-8 (0-0.6 μM; 48 hours) suppresses the expression of EGFR and c-Met in these five cell lines irrespective of their mutational status. EGFR-IN-8 (0-20 μM; 24, 48, 72 hours) exhibits a time- and dose-dependent inhibitory effect on the viability of A549, PC9, H1975, CL68, and CL97?cells at different time intervals, with IC50 values ranging from 0.3 to 0.6?μM and 0.2-0.5?μM after 48 and 72?h of treatment respectively[1]. |
| 體內(nèi)活性 | EGFR-IN-8 (50,150?mg/kg; oral gavage) exhibits suppression (29% and 60%, respectively) of H1975 xenograft tumor growth in a dose-dependent manner[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : ＜1 mg/mL (insoluble or slightly soluble), Sonication is recommended. |
| 關(guān)鍵字 | inhibit | Epidermal growth factor receptor | EGFR IN 8 | ErbB-1 | HER1 | Inhibitor | c-Met/HGFR | EGFRIN8 | EGFR-IN-8 | EGFR |
| 相關(guān)產(chǎn)品 | Osimertinib | Lidocaine Hydrochloride hydrate | L-Ascorbic acid 2-phosphate trisodium | Lapatinib | Afatinib Dimaleate | Erlotinib hydrochloride | Erlotinib | Neratinib | Chalcone | Genistein | Khellin | Gefitinib |
| 相關(guān)庫 | 抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 激酶抑制劑庫 | 酪氨酸激酶分子庫 | 抗乳腺癌化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 共價(jià)抑制劑庫 | 抗肝癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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