Eflornithine hydrochloride hydrate NEW
| Price | $42 | $124 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Eflornithine hydrochloride hydrate | CAS No.: 96020-91-6 |
| Purity: 99.64% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Eflornithine hydrochloride hydrate |
| 描述 | Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific and irreversible inhibitor of the ornithine decarboxylase (ODC). Eflornithine hydrochloride hydrate has antitumor activity and has also been used in the hirsutism Eflornithine hydrochloride hydrate has antitumor activity and is also used in the treatment of hirsutism. |
| 細(xì)胞實驗 | BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. (Only for Reference) |
| 體外活性 | When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1]. |
| 體內(nèi)活性 | Eflornithine stands as the only novel compound registered for human African trypanosomiasis treatment in the past five decades, primarily serving as an alternative for cases resistant to melarsoprol involving Trypanosoma brucei gambiense. Additionally, a 15% eflornithine cream demonstrates efficacy superior to placebo in diminishing excessive, unwanted facial hair growth in patients, with 58% of individuals treated with eflornithine observing at least some improvement in facial hirsutism after 24 weeks, compared to 34% of those receiving placebo. Furthermore, the inhibitory effect on hair growth by eflornithine cream is significantly amplified when applied to mouse skin previously treated with microneedles. In hypertensive rats with coarctation, eflornithine treatment normalizes contractile responses to KCI and norepinephrine, and enhances relaxations to acetylcholine within 14 days, indicating its broader pharmacological utility. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (232.42 mM) |
| 關(guān)鍵字 | inhibit | DFMO hydrochloride | α-difluoromethylornithine hydrochloride | α-difluoromethylornithine hydrochloride Hydrate | RMI-71782 hydrochloride Hydrate | Eflornithine hydrochloride Hydrate | Eflornithine Hydrochloride | Eflornithine hydrochloride hydrate | MDL-71782 hydrochloride Hydrate | Inhibitor | a-difluoromethylornithine hydrochloride Hydrate | Difluoromethylornithine hydrochloride Hydrate | MDL-71782 hydrochloride | RMI-71782 hydrochloride | Parasite | DFMO hydrochloride Hydrate |
| 相關(guān)產(chǎn)品 | α-Hydroxyglutaric Acid Lithium | Carbidopa monohydrate | L-Ornithine | Carbidopa | 4-Bromo-3-hydroxybenzoic acid | Tritoqualine |
| 相關(guān)庫 | 高選擇性抑制劑庫 | 抗寄生蟲庫 | 經(jīng)典已知活性庫 | 上市藥物庫 | ReFRAME 相關(guān)化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | FDA 上市藥物庫 | 代謝化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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