E7016 NEW

Price	$132	$328	$496
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-14

Product Details

Product Name: E7016	CAS No.: 902128-92-1
Purity: 98.16%	Supply Ability: 10g
Release date: 2024/11/14

Product Introduction

Bioactivity

名稱(chēng)	E7016
描述	E7016 (GPI 21016) is an orally available PARP inhibitor that inhibits DNA repair and enhances tumor cell radiosensitivity both in vitro and in vivo.
體外活性	E7016 (3 μM) enhances radiosensitization by an increase in the number of cells undergoing mitotic catastrophe and not an increase in the number of cells undergoing apoptosis[1]. E7016 inhibits PARP by mimicking NAD+[2].
體內(nèi)活性	Administration of E7016 (40 mg/kg; oral gavage) to mice bearing U251 xenografts enhances the effectiveness of the Temozolomide/radiation combination. Mice treated with E7016/irradiation/Temozolomide have an additional growth delay of six days compared with the combination of irradiation/Temozolomide in vivo[1].
存儲(chǔ)條件	Shipping with blue ice.
溶解度	DMSO : 22.5 mg/mL (64.4 mM), Sonication and heating to 60℃ are recommended.
關(guān)鍵字	E-7016 \| E7016 \| GPI-21016 \| E 7016 \| GPI21016
相關(guān)產(chǎn)品	4'-Methoxychalcone \| Niraparib tosylate monohyrate \| VPC-70063 \| 3-Aminobenzamide \| XAV-939 \| Niraparib \| 3-Methoxybenzamide \| NU1025 \| Olaparib \| Benzamide \| Picolinamide \| OUL35
相關(guān)庫(kù)	DNA 損傷和修復(fù)分子庫(kù) \| 經(jīng)典已知活性庫(kù) \| 抗癌臨床化合物庫(kù) \| 藥物功能重定位化合物庫(kù) \| 抑制劑庫(kù) \| 抗衰老化合物庫(kù) \| 已知活性化合物庫(kù) \| 抗癌化合物庫(kù) \| 抗癌藥物庫(kù) \| 抗癌活性化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.