Product Details
| Product Name:
Butyzamide |
CAS No.:
1110767-45-7 |
| Purity:
99% |
Supply Ability:
10g |
| Release date:
2024/11/11 |
Product Introduction
Bioactivity
| 名稱(chēng) | Butyzamide |
| 描述 | Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials. |
| 體外活性 | Butyzamide (3 μM; 15 minutes) induces phosphorylation of JAK2, STAT3, STAT5, and MAPK in Ba/F3-hMpl cells.[1]
Butyzamide (3 μM; 48 hours) induces colony-forming unit-megakaryocyte (CFU-MK) and polyploid megakaryocyte formation in human CD34+ hematopoietic progenitor cells.[1] |
| 體內(nèi)活性 | Butyzamide (10 mg/kg, 50 mg/kg; oral administration; once daily for 20 days) enhances human platelet levels in NOG mice transplanted with human fetal liver-derived CD34+ cells.[1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 225.0 mg/mL (751.7 mM), Sonication is recommended.
|
| 關(guān)鍵字 | Butyzamide |
| 相關(guān)產(chǎn)品 | Delgocitinib | Deucravacitinib | Fedratinib | RO8191 | Ruxolitinib | Tofacitinib Citrate | CEP-33779 | Ruxolitinib phosphate | JAK-IN-10 | Baricitinib | Tofacitinib | Ritlecitinib |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 激酶抑制劑庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:1953-02-2
$29.00 / 1mL
-
CAS:902128-92-1
$132.00 / 1mg
-
CAS:926259-99-6
$34.00 / 5mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States