Product Details
| Product Name:
Durvalumab |
CAS No.:
1428935-60-7 |
| Purity:
95.3% (SEC-HPLC) |
Supply Ability:
10g |
| Release date:
2024/11/13 |
Product Introduction
Bioactivity
| 名稱(chēng) | Durvalumab |
| 描述 | Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and 0.04 nM, respectively. Durvalumab is often used in combination with platinum-based compounds for the treatment of non-small cell lung cancer and advanced hepatocellular carcinoma cells. |
| 體內(nèi)活性 | In a mouse xenograft model of human melanoma ( A375 ) and pancreatic ( HPAC ) tumor cell lines, Durvalumab inhibits tumor growth through a T cell-mediated mechanism. Compared with the isotype-matched control antibody Durvalumab, both HPAC and A375 xenografts significantly inhibited tumor growth ( 5-0.01 mg / kg for NOD / SCID mice with HPAC tumors ; 5-0.1mg / kg for NOD / SCID mice with A375 tumor ; intraperitoneal administration ; twice a week ; for 3 weeks ), 74 % HPAC cell growth inhibition and 77 % A375 cell growth inhibition were achieved. However, when administered in the absence of T cells, Durvalumab had no effect on the growth of A375 tumor xenografts. [ 2 ] |
| 存儲(chǔ)條件 | store at low temperature | store at -20°C | Shipping with blue ice. |
| 關(guān)鍵字 | MEDI-4736 | MEDI4736 | Durvalumab |
| 相關(guān)產(chǎn)品 | LSD1-IN-24 | PD-1/PD-L1-IN-9 | Sulfamethoxypyridazine | PD-1-IN-22 | BMS-202 | BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride | IMMH 010 maleate | BMS-8 | LSD1-IN-27 | PD-1/PD-L1-IN-10 | BMS-1 | PD-L1-IN-3 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$228.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-13 |
United States