Clemastine fumarate NEW
| Price | $38 | $51 | $76 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Clemastine fumarate | CAS No.: 14976-57-9 |
| Purity: 99.8% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Clemastine fumarate |
| 描述 | Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
| 體外活性 | In rats, Clemastine Fumarate (5-20 mg/kg) significantly inhibits yeast polysaccharide-induced paw edema and croton oil-induced ear swelling in a dose-dependent manner. |
| 體內活性 | In HL-60 cells, Clemastine Fumarate (IC50=3 nM) effectively inhibits histamine-induced increases in Ca2+ levels. In the human leukemia cell line K562 and the human B-lymphoblast cell line SB, concentrations of Clemastine Fumarate ≥25 μM significantly suppress both natural killer (NK) cell and antibody-dependent cell-mediated cytotoxicity (ADCC) activities. Additionally, Clemastine Fumarate potently inhibits the HERG K+ channel in HEK 293 cells stably expressing the channel (IC50=12 nM). |
| 存儲條件 | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 9 mg/mL (19.57 mM), Sonication is recommended. |
| 關鍵字 | Inhibitor | Histamine Receptor | oral | H1 receptor | Clemastine Fumarate | Clemastine | Autophagy | HS 592 | Meclastine Fumarate | inhibit | HS592 | Clemastine fumarate | Meclastine | antihistamine | allergic reactions | anti-inflammatory | HS-592 |
| 相關產品 | Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib |
| 相關庫 | 神經退行性疾病化合物庫 | 經典已知活性庫 | 疼痛相關化合物庫 | 膜蛋白靶向化合物庫 | 抗癌臨床化合物庫 | 抑制劑庫 | FDA 上市藥物庫 | 抗衰老化合物庫 | GPCR靶點分子庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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