Vonoprazan fumarate NEW
| Price | $40 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Vonoprazan fumarate | CAS No.: 1260141-27-2 |
| Purity: 99.16% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Vonoprazan fumarate |
| Description | Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase. |
| In vitro | TAK-438 has demonstrated effective and sustained inhibition of gastric acid secretion stimulated by histamine in both rats and dogs. This compound exhibits notable antisecretory activity through its high accumulation in gastric tissue and low clearance rate. Unlike PPIs (Proton Pump Inhibitors), TAK-438's efficacy is not influenced by the state of gastric secretion. It inhibits basal gastric acid secretion in a dose-dependent manner, with an ID50 value of 1.26 mg/kg. Intravenous administration of TAK-438 increases the pH of gastric perfusate in a dose-dependent way, maintaining the rise in pH for up to five hours. When treated with 1 mg/kg of TAK-438, the pH value reached a stable state after 90 minutes, with a maximum pH of 5.9. |
| In vivo | TAK-438 inhibits the activity of gastric H+,K+-ATPase in a concentration-dependent manner. Its inhibitory effect remains almost unchanged under neutral (pH 7.5) and slightly acidic conditions (pH 6.5). Even at concentrations 500 times higher than its IC50 for gastric H+,K+-ATPase activity, TAK-438 does not inhibit Na+,K+-ATPase activity. TAK-438 inhibits gastric H+,K+-ATPase competitively with potassium (K+), with an inhibition constant (Ki) of 3 nM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 16.67 mg/mL (36.12 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Vonoprazan fumarate | TAK 438 | TAK438 | Vonoprazan Fumarate |
| Inhibitors Related | Sodium oleate | trans-Aconitic acid | Phlorizin | Revaprazan hydrochloride |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library | Fluorochemical Library | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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