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Postion:Product Catalog >BI-4142
BI-4142
  • BI-4142

BI-4142 NEW

Price $226 $562 $883
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: BI-4142 CAS No.: 2682003-36-5
Purity: 98.09% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameBI-4142
DescriptionBI-4142 is an orally active, potent and selective HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling.
In vitroBI-4142 inhibits HER2-dependent cell lines and downstream signaling, with IC50 values of 10 nM, 18 nM, 270 nM, and 2400 nM against HEK HER2YVMA, Ba/F3 HER2YVMA, HEK EGFRWT, and Ba/F3 EGFRWT, respectively[1].BI-4142 (1 nM-5 μM, 72?h or 96?h) exhibits antiproliferative activity against tumor cells[1]. In the CaCo-2 assay, BI-4142 displays good permeability and no PgP-mediated efflux liability[1].
In vivoBI-4142 administered at doses ranging from 0 to 100 mg/kg, orally twice daily for 40 days, significantly inhibits tumor growth and suppresses oncogenic signaling[1].
StorageShipping with blue ice.
Solubility InformationDMSO : 80 mg/mL (153.38 mM), Sonication is recommended.
Inhibitors RelatedTucatinib | AG-1478 | (S)-Afatinib | Mollugin | Tannic acid | Afatinib Dimaleate | Neratinib | Cisapride | Pyrotinib dimaleate | AG1557 | Sarizotan 2HCl | VU 0240551
Related Compound LibrariesBioactive Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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