Product Details
| Product Name:
Bemnifosbuvir |
CAS No.:
1998705-64-8 |
| Purity:
99.35% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Bemnifosbuvir |
| Description | Bemnifosbuvir (AT-511), a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate, exhibits potent in vitro activity against HCV. |
| In vitro | Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV[1].In the absence of cells, Bemnifosbuvir was stable when incubated in culture medium at 37°C for up to 24 h. AT-9010 was the predominant intracellular metabolite measured in all hepatocyte species and Huh-7 cell incubations with 10 μM Bemnifosbuvir and, except in mouse hepatocytes,far exceeded intracellular Bemnifosbuvir concentrations,demonstrating that the active TP was efficiently formed from its phosphoramidate protide in liver cells. In hepatocyte incubations, the relative levels of AT-9010 formed, and its accumulation over 24 h expressed as area under the curve or AUC0-24h; from most to least abundant, were rat>human >mouse >dog/monkey. |
| In vivo | Treatment with moxifloxacin every 8hr was accompanied by longer survival than in any other group.Tissue cultures 30hr after bacterial challenge showed considerably less bacterial growth in the spleens and lungs of moxifloxacin-treated animals than in the other groups, but not in their livers[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 95 mg/mL (163.36 mM)
|
| Keywords | guanosine | pangenotypic | Hepatitis C virus | SARS coronavirus | inhibit | HCV | Inhibitor | antiviral | AT511 | Bemnifosbuvir | AT 511 | SARS-CoV | nucleotide | phosphoramidate |
| Inhibitors Related | Nirmatrelvir | EIDD-1931 | Remdesivir | Ribavirin | Silymarin | Umifenovir hydrochloride | Sofosbuvir | Hydroxychloroquine | Ritonavir | Chloroquine phosphate | Artemisinin | Favipiravir |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Infection Compound Library | Nucleotide Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States